Search results for "macrophage repolarization"

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HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Exper…

2021

Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have therapeutic potential in the treatment of several immune disorders, including ulcerative colitis, owing to their regenerative and immunosuppressive properties. We recently showed that MSCs engineered to overexpress hypoxia-inducible factor 1-alpha and telomerase (MSC-T-HIF) and conditioned with pro-inflammatory stimuli release EVs (EVMSC-T-HIFC) with potent immunomodulatory activity. We tested the efficacy of EVMSC-T-HIFC to repolarize M1 macrophages (Mφ1) to M2-like macrophages (Mφ2-like) by analyzing surface markers and cytokines and performing functional assays in co-culture, including efferocytosis and T-cel…

MaleCrohn’s diseasemedicine.medical_treatmentimmunomodulationMiceIntestinal mucosaCrohn DiseaseMedicineBiology (General)TelomeraseSpectroscopyCell PolarityGeneral MedicineComputer Science ApplicationsChemistryCytokinemacrophage repolarizationhypoxia-inducible factor 1-alphaCytokinesmesenchymal stromal cellsMyofibroblastGastroenterología y hepatologíaQH301-705.5CatalysisArticleInorganic ChemistryExtracellular VesiclesYoung AdultImmune systemCell AdhesionHuman Umbilical Vein Endothelial CellsAnimalsHumansPhysical and Theoretical ChemistryColitisEfferocytosisQD1-999Molecular BiologyAcute colitisbusiness.industryOrganic ChemistryMesenchymal stem cellMesenchymal Stem Cellsmedicine.diseaseHypoxia-Inducible Factor 1 alpha SubunitDisease Models AnimalTrinitrobenzenesulfonic AcidCancer researchbusiness
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